The highway closed after rocks covered the northbound lane at mile 111, near McHugh Creek. A second rock slide was reported near mile 106.5.
Rockfall along the Seward Highway near Beluga Point has been happening since wind and rain battered the area earlier this week.
Authorities warned that drivers should use caution in the area due to the potential for additional rockslides.
Officials cited rockfall danger and traffic hazards created by people stopping to fill containers.
A woman was trapped in a pickup on the Seward Highway on Friday after falling ice crushed the vehicle just south of Anchorage.
3-17-12 Ice formation on cliffs - Anchorage, Alaska, USA